Retro-Claisen benzylation: direct use of benzyl alcohols in Pd-catalyzed couplings with nitriles.
نویسندگان
چکیده
A new strategy has been developed for the benzylation of nitriles directly from benzyl alcohols. In this process benzyl alcohols undergo retro-Claisen activation with cyanoacetic esters to generate an active electrophile and a carbanionic nucleophile. In the presence of Pd(0) these intermediates undergo catalytic coupling to generate a new C-C bond, resulting in the formation of phenyl propionitriles.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical communications
دوره 50 90 شماره
صفحات -
تاریخ انتشار 2014